What Is HGH Fragment 176-191?

The full growth hormone molecule contains 191 amino acids, and it performs many jobs at once. Scientists wondered whether one small region carried the fat related activity alone. Early work in the 1990s pointed to the C-terminal tail, which sits at positions 176 through 191. That finding launched decades of interest in this fragment, and it explains why people now search for it under names like HGH fragment, hgh 176 191 fragment, and Frag 176-191.

Fragment 176-191 vs AOD-9604

People confuse these two constantly, so a clear distinction helps. AOD-9604 is a modified version of the same tail region. Its developers added a tyrosine residue at the front to improve stability. Fragment 176-191, in contrast, keeps the unmodified natural sequence. Both appear under similar labels in the research market, and the human trial history belongs to AOD-9604, not to the bare fragment. We explain that gap in detail below, because honest buyers deserve the full picture.

Why Researchers Still Pay Attention

Growth hormone drives lipolysis, which means it helps break down stored fat. However, it also affects blood sugar and tissue growth, and those effects limit its use. The fragment idea promised the fat related benefit without the baggage. Consequently, laboratories continue to study the tail region as a model for targeted metabolic signaling.

Buy HGH Fragment 176-191: Choose Your Format

Every format below ships with an HPLC chromatogram, a mass spectrometry identity result, and a handling guide.

HGH Fragment 176-191 5mg Vial

The 5mg vial fits shorter research cycles and conservative protocols. Labs reconstitute the powder with bacteriostatic water and split it into small daily amounts.

Concentration: 5mg per vial
Purity: 98 percent minimum, HPLC verified, third party tested
Includes: reconstitution guide, storage card, COA
Delivery: 1 to 2 business days, discreet packaging, full tracking

HGH Fragment 176-191 10mg Vial

The 10mg vial supports full length cycles and lowers the cost per milligram. Researchers who plan eight to twelve week courses usually choose this size.

Concentration: 10mg per vial
Purity: 99 percent minimum, HPLC verified, third party tested
Includes: full protocol reference, reconstitution guide, COA
Delivery: 1 to 2 business days, discreet packaging, full tracking

Where to Buy HGH Fragment 176-191 Safely

Most buyers find the compound through a quick search, then face a wall of nearly identical storefronts. Unfortunately, many of those sellers sell AOD-9604 under a fragment label, or the reverse, and a vague listing hides the difference. Therefore, run every seller, including us, through the checklist below.

What to verify	Peptide Near Me	Typical marketplace seller
Sequence clearly stated (176-191 or modified)	Yes	Often blurred
Lot matched COA for every batch	Yes	Rarely
HPLC purity result shown	Yes	Sometimes
Mass spectrometry identity check	Yes	Almost never
Research use only labeling	Yes	Inconsistent
Real support contact	Yes	Often none
Shipping time	1 to 2 business days	5 to 10 days

A lot matched COA connects the lab report to the exact batch you receive. As a result, you can compare the lot number on your vial with the document in minutes. If a seller cannot offer that comparison, you cannot verify what you bought.

Questions before you order? Contact our team, and a real person will answer.

What Does the Research Say About HGH Fragment 176-191?

Let us state the evidence plainly. No controlled human trial has tested the unmodified fragment for fat loss. The data come from animal and laboratory work, plus one closely related compound that did reach human trials. You can explore the published literature on PubMed.

Laboratory and Animal Findings

Rat fat pad experiments localized the anti lipogenic activity of growth hormone to the C-terminal region. In those studies, a close relative of the fragment matched whole growth hormone in blocking fat formation, although it showed no meaningful lipolytic effect. Meanwhile, work on the stabilized AOD-9604 version reported reduced weight gain in obese rodents without harming insulin sensitivity.

The Human Trial Record

The modified cousin, AOD-9604, did reach people. Safety studies found no effect on IGF-1 levels, no negative effect on glucose tolerance, and no antibodies against the peptide. However, the pivotal 24 week Phase 2b obesity trial enrolled 536 participants and failed to show significant weight loss compared with placebo. The developer terminated the program in 2007.

What This Means for Buyers

Rodent results did not translate into human weight loss for the best studied version of this fragment. Consequently, no one can promise fat loss from the bare sequence, and we make no such promise. We offer it so qualified researchers can work with a documented, verified material.

HGH Fragment 176-191 Dosage: Reference Ranges From Community Reports

No regulator has approved a dose, and no human trial of the bare fragment exists. The table below summarizes the ranges that researchers and community sources report. Treat it as a reference point, not as instruction.

Parameter	Commonly reported range
Daily amount	250 to 500 mcg
Frequency	Once or twice per day
Timing	Fasted, often morning
Route	Subcutaneous injection
Course length	8 to 12 weeks, then a break

Notice how consistent the fasted timing appears. Researchers believe that insulin from a recent meal could blunt any lipolytic signal, so they space dosing away from food. Still, that idea remains a hypothesis. Searches for hgh fragment 176 191 dosage all end at the same honest answer: no standard exists.

Reconstitution and Storage

Reconstitute the lyophilized powder with bacteriostatic water by directing the stream along the vial wall, not onto the powder. Swirl gently, never shake. Store unreconstituted vials in a cool, dark place, and refrigerate once mixed. Moreover, follow the use by window printed in the handling guide, since peptides degrade faster in solution than in powder form.

HGH Fragment 176-191 vs Other Metabolic Research Compounds

Researchers rarely evaluate this fragment alone. They compare it with other compounds that target fat metabolism through different pathways.

	Fragment 176-191	AOD-9604	5-Amino-1MQ	CBL-514
Origin	Natural GH tail	Stabilized GH tail	NNMT enzyme inhibitor	Fat cell apoptosis compound
Human trial data	None for bare fragment	Phase 2b, missed endpoint	None published	Phase 3 underway
Main research angle	Lipogenesis models	Lipolysis models	Adipose enzyme activity	Localized fat reduction
Route	Injection	Injection or oral	Oral or injection	Injection

If you want to study alternatives, visit our product pages for 5-Amino-1MQ and CBL-514, or open the full Weight and Metabolism category. For growth hormone axis research, see the Sleep and Growth Hormone category.

Side Effects and Safety Considerations

Preclinical toxicology studies on the stabilized version found no genotoxicity or significant toxicity concerns. Even so, safety data on the bare fragment in people barely exist. Researchers report injection site redness, mild headache, and occasional lightheadedness, although no controlled study confirms these reports.

Who Should Avoid It

Pregnant and breastfeeding individuals should not use this compound. People with diabetes or metabolic disease should speak with a physician first, because any growth hormone related molecule deserves caution. Similarly, anyone with a cancer history needs medical guidance before using a growth hormone pathway compound.

A Note for Athletes

The World Anti-Doping Agency prohibits growth hormone fragments at all times. Therefore, competitive athletes risk a violation by using it.

Regulatory Status in 2026

The FDA has not approved HGH Fragment 176-191 for any use, and it holds no recognized compounding status. Retailers sell it exclusively as a research compound, not for human or veterinary use and not as a supplement. For the rules that govern compounding, consult the FDA compounding guidance. Additionally, you can check for registered studies on ClinicalTrials.gov.

Ready to Buy HGH Fragment 176-191?

You now understand where the fragment comes from, how it differs from AOD-9604, and what the evidence does and does not show. One decision remains, and it controls what lands at your door: the source. Every vial we ship carries a lot matched COA, and we run HPLC and mass spectrometry checks before any batch enters inventory. Orders placed before 2pm leave the same day, and our team answers every message personally.

Add the 5mg vial to your cart. Add the 10mg vial to your cart. Ask us a question first.

Discreet outer packaging. Full tracking from dispatch. Delivery to all 50 states.

Looking for something else? Explore the Recovery and Repair category, the Anti Aging and Skin category, or our Stacks and Bundles.

Frequently Asked Questions About HGH Fragment 176-191

What is HGH Fragment 176-191?

It is the C-terminal tail of human growth hormone, spanning amino acids 176 through 191. Researchers study it as a model for fat metabolism signaling.

Where can I buy HGH Fragment 176-191 online?

You can order it from our store as a research compound. Wherever you shop, confirm that the seller publishes a lot matched COA with HPLC purity and an identity result.

Is HGH Fragment 176-191 the same as AOD-9604?

No. AOD-9604 adds a tyrosine residue to a closely related sequence to improve stability. The two molecules behave similarly in some models, but only AOD-9604 reached human trials.

What is the typical HGH Fragment 176-191 dosage?

No standard exists. Community sources describe 250 to 500 mcg daily by subcutaneous injection, often fasted, in courses of 8 to 12 weeks.

Does HGH Fragment 176-191 work for fat loss?

No controlled human trial has proven it. The related compound AOD-9604 failed to beat placebo in a 536 person, 24 week study, so nobody should expect guaranteed results.

What are the side effects?

Researchers report mild injection site reactions, headache, and lightheadedness. However, controlled human safety data for the bare fragment do not exist.

Is HGH Fragment 176-191 legal to buy in the US?

Retailers can sell it for research use only. The FDA has not approved it, and it has no recognized compounding pathway.

Can athletes use HGH Fragment 176-191?

No. WADA lists growth hormone fragments as prohibited at all times.

How should I store the vial?

Keep dry powder cool and dark. After reconstitution, refrigerate it and use it within the window printed in the handling guide.

Can I combine it with other peptides?

Researchers sometimes pair it with growth hormone secretagogues, but no human data support any combination. Consult a physician before attempting a stack.